I attended the panel discussion entitled 'The World of Publishing', the panel being John Jarrold (my agent), Lee Harris (editor of Angry Robot), Julie Crisp (editorial director of Tor), Jon Weir (publicity manager for Gollanz) and David Thomas Moore and editor).
On the subject of self-publishing the panel was surprisingly dismissive. They acknowledged that some new writers had come thru the Kindle ranks but noted that these were amazingly small in number (a handful out of the 3 million books self-published last year in the States) so really nothing much has changed.
There was a comment that some writers, tho' talented, had written books which were perceived as not commercial enough (been there with 'Dark Charismatic'!).
They also looked for enthusiasm in their writers: if a writer wasn't passionate about their work then i) it showed in their work and ii) how were they supposed to be enthused about a book if the writer wasn't.
Food for thought.